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KMID : 0371620020170010085
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Journal of Wonkwang Medical Science
2002 Volume.17 No. 1 p.85 ~ p.91
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One Case of Asymptomatic Pulmoary Alveolar Proteinois discovered incidentally by Chest Roentgenography
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Park Jung-Hyun
Kim Hak-Ryul
Yang Sei-Hoon
Jeong Eun-Taik
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Abstract
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Pulmonary Alveolar proteinosis (PAP) is an uncommon diffuse lung disease of unknown etiology that is characterized by the accumulation of large amounts of a phospholipoproteinaceous material in the alveoli. It has a variable clinical presentation and course. Most cases are primary but some cases are secondary to other conditions or inhalation of chemicals. Its pathogenesis is believed to involve abnormalities of surfactant homeostasis and recently, animal experiments suggest that this may be related, in some instances at least, to defects in GM-CSF signalling. Although the causative treatment of PAP is not well known, whole lung lavage still remains the safest and the most effective treatment with overall good prognosis. Because of possibility of increasing incidence, non-inflammatory alveolar disease with unknown etiology must be differentiated from PAP. We presented one case of asymptomatic PAP, which was found incidentally through chest X-ray and confirmed by light and electron microscopic examination of lung tissues obtained by open lung biopsy & bronchoalveolar lung lavage.
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KEYWORD
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Pulmonary alveolar proteinosis, Bronchoalveolar lavage
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